THE ROLE OF PREOPERATIVE REGIONAL CHEMOTHERAPY FOR COLORECTAL METASTASES IN POOR PROGNOSIS PATIENTS
https://doi.org/10.17650/2220-3478-2013-0-4-42-49
Abstract
In this study we have analyzed 120 cases of extensive liver resection with pre- and postoperative regional chemotherapy in poor prognosis patients: 54 (45 %) of them had multiple liver metastases, 72 (60 %) – had bilobar lesions, 26 (22 %) had extrahepatic metastases. Adding bevacizumab to preoperative regional intra-arterial chemotherapy (FOLFOX) has increased objective response rate up to 65 vs 44 % in group without bevacizumab and grade III morphological response rate up to 59 vs 5 % in group without bevacizumab.Difference in overall survival in both groups was not statistically significant: 5-year survival was 16 ± 8 % and 21 ± 6 %, median survival was 35 months and 29 months in groups with or without bevacizumab, respectively.Preoperative regional intra-arterial chemotherapy has not increased the rate of bleeding and postoperative complications.
About the Authors
S. A. Lazarev
The Altai branch of N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Barnaul
Russian Federation
Russian Federation
A. F. Lazarev
The Altai branch of N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Barnaul
Russian Federation
Russian Federation
K. G. Mamontov
The Altai branch of N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Barnaul
Russian Federation
Russian Federation
A. G. Kotelnikov
The Altai branch of N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Barnaul
Russian Federation
Russian Federation
S. L. Khays
The Altai branch of N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Barnaul
Russian Federation
Russian Federation
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