RECTAL CANCER RECURRENCES FOLLOWING SURGICAL AND COMBINED TREATMENT: RISK FACTORS, DIAGNOSTICS AND TREATMENT
https://doi.org/10.17650/2220-3478-2013-0-3-32-39
Abstract
Diagnostic and treatment of rectal cancer local recurrences, risk factors and treatment tactics are discussed in this article. Chemoradio-therapy is a method of choice as the first stage of treatment for this patient group, however its application is limited by pelvic radiotherapy anamnesis. Surgery is the only method of potentially curative treatment, but it should be applied only in patients with high probability of R0-resection.
About the Authors
T. Pu
I.M. Sechenov First Moscow State Medical University;
Russian Federation
Russian Federation
Department of Oncology
A. O. Rasulov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Department of Surgery №3
Russian Federation
Department of Surgery №3
R. I. Tamrazov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Department of Surgery №3
Russian Federation
Department of Surgery №3
S. S. Gordeyev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Department of Surgery №3
Russian Federation
Department of Surgery №3
References
1. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2011 году (заболеваемость и смертность). ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России, 2013.
2. Peeters K.C., Marijnen C.A., Nagtegaal I.D. et al. The TME trial after a median follow-up of 6 years: increased local control but nosurvival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 2007;246(5):693–701.
3. Sauer R., Becker H., Hohenberger W. et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351(17):1731–40.
4. Ortiz H., Wibe A., Ciga M.A. et al. Impact of a multidisciplinary team trainingprogramme on rectal cancer outcomes in Spain. Colorectal Dis 2013;15(5):544–51.
5. Martling A., Holm T., Rutqvist L.E. et al. Impact of a surgical training programme on rectal cancer outcomes in Stockholm. Br J Surg 2005;92(2):225–9.
6. Farouk R., Nelson H. and Gunderson L.L. Aggressive multimodality treatment for locally advanced irresectable rectal cancer. Br J Surg 1997; 84(6):741–9.
7. Wong C.S., Cummings B.J., Brierley J.D. et al. Treatment of locally recurrent rectal carcinoma--results and prognostic factors. Int J Radiat Oncol Biol Phys 1998;40(2):427–35.
8. Jörgren F., Johansson R., Damber L., Lindmark G. Risk factors of rectal cancer local recurrence: population-based survey and validation of the Swedish rectal cancer registry. Colorectal Dis 2010;12(10):977–86.
9. Williams N.S. and Abulafi A.M. Local recurrence of colorectal cancer: the problem, mechanisms, management and adjuvant therapy. Br J Surg 1994;81(1):7–19.
10. Chen G. et al. Causes of recurrence in low rectal carcinoma after low anastomosis operation. Clin J Med Officers 2010;38(4):503–5.
11. Koca D., Binicier C., Oztop I. et al. Prognostic factors affecting recurrence and survival in patients with locally advanced rectal cancer. J BUON 2012;17(2):291–8.
12. Wu Z.Y. et al. Risk factors of local recurrence after curative resection in patients with middle and lower rectal carcinoma. Chin J Pract Surg 2008;28(2):133–5.
13. Liebig C., Ayala G., Wilks J. et al. Perineural invasion is an independent predictor of outcome in colorectal cancer. J Clin Oncol 2009;27(31):5131–7.
14. Wang L.M., Kevans D., Mulcahy H. et al. Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. Am J Surg Pathol 2009;33(1):134–41.
15. NCCN Clinical Practice Guidelines in Oncology: Rectal Cancer. V. 2. 2012.URL: http://www.nccn.org (дата обращения 01.03.2012).
16. Sauer R., Liersch T., Merkel S. et al. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol 2012;30(16):1926–33.
17. Ceyhan G.O., Liebl F., Maak M. et al. The severity of neural invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapy. Ann Surg 2010;252(5):797–804.
18. Li C.S., Wan D.S., Pan Z.Z. et al. [Multivariate prognostic analysis of patients with low and middle rectal cancer after curative resection]. Ai Zheng 2006;25(5):587–90.
19. Kim J.C., Yu C.S., Lim S.B. et al. Abdominoperineal resection and low anterior resection: comparison of long-term oncologic outcome in matched patients with lower rectal cancer. Int J Colorectal Dis 2013;28(4):493–501.
20. Wibe A., Syse A., Andersen E. et al. Oncological outcomes after total mesorectal excision for cure for cancer of the lower rectum: anterior vs. abdominoperineal resection. Dis Colon Rectum 2004;47(1):48–58.
21. West N.P., Anderin C., Smith K.J. et al. Multicentre experience with extralevator abdominoperineal excision for low rectal cancer. Br J Surg 2010;97(4):588–99.
22. Birbeck K.F., Macklin C.P., Tiffin N.J. et al. Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery. Ann Surg 2002;235(4):449–57.
23. Guillem J.G., Paty P.B. and Cohen A.M. Surgical treatment of colorectal cancer. CA Cancer J Clin 1997;47(2):113–28.
24. Williams N.S. The rationale for preservation of the anal sphincter in patients with low rectal cancer. Br J Surg 1984;71(8):575–81.
25. Kusters M., Beets G.L., van de Velde C.J. et al. A comparison between the treatment of low rectal cancer in Japan and the Netherlands, focusing on the patterns of local recurrence. Ann Surg 2009;249(2):229–35.
26. Moriya Y., Sugihara K., Akasu T., Fujita S. Importance of extended lymphadenectomy with lateral node dissection for advanced lower rectal cancer. World J Surg 1997;21(7):728–32.
27. Georgiou P., Tan E., Gouvas N. et al. Extended lymphadenectomy versus conventional surgery for rectal cancer: a meta-analysis. Lancet Oncol 2009;10(11):1053–62.
28. Dresen R.C., Peters E.E., Rutten H.J. et al. Local recurrence in rectal cancer can be predicted by histopathological factors. Eur J Surg Oncol 2009;35(10):1071–7.
29. Bülow S., Christensen I.J., Iversen L.H. et al. Intra-operative perforation is an important predictor of local recurrence and impaired survival after abdominoperineal resection for rectal cancer. Colorectal Dis 2011;13(11):1256–64.
30. Suzuki K., Dozois R.R., Devine R.M. et al. Curative reoperations for locally recurrent rectal cancer. Dis Colon Rectum 1996;39(7):730–6.
31. Wanebo H.J., Antoniuk P., Koness R.J. et al. Pelvic resection of recurrent rectal cancer: technical considerations and outcomes. Dis Colon Rectum 1999;42(11):1438–48.
32. Hahnloser D., Nelson H., Gunderson L.L. et al. Curative potential of multimodality therapy for locally recurrent rectal cancer. Ann Surg 2003;237(4):502–8.
33. Enríquez-Navascués J.M., Borda N., Lizerazu A. et al. Patterns of local recurrence in rectal cancer after a multidisciplinary approach. World J Gastroenterol 2011;17(13):1674–84.
34. Kusters M., Marijnen C.A., van de Velde C.J. Patterns of local recurrence in rectal cancer; a study of the Dutch TME trial. Eur J Surg Oncol 2010;36(5):470–6.
35. Höcht S., Mann B., Germer C.T. et al. Pelvic sidewall involvement in recurrent rectal cancer. Int J Colorectal Dis 2004;19(2):108–13.
36. Kim T.H., Jeong S.Y., Choi D.H. et al. Lateral lymph node metastasis is a major cause of locoregional recurrence in rectal cancer treated with preoperative chemoradiotherapy and curative resection. Ann Surg Oncol 2008;15(3):729–37.
37. Ефетов В.М., Ефетов С.В., Черипко О.Н. Рецидивы рака прямой кишки. Онкология 2006;8(2):176–180.
38. Gu J.Z. Clinical path of diagnosis and treatment for locally recurrent rectal cancer. Chin J Pract Surg 2011;31(4):277–80.
39. Kodeda K., Derwinger K., Gustavsson B., Nordgren S. Local recurrence of rectal cancer: a population-based cohort study of diagnosis, treatment and outcome. Colorectal Dis 2012;14(5):e230–7.
40. Heriot A.G., Byrne C.M., Lee P. et al. Extended radical resection: the choice for locally recurrent rectal cancer. Dis Colon Rectum 2008;51(3):284–91.
41. Palmer G., Martling A., Cedermark B., Holm T. A population-based study on the management and outcome in patients with locally recurrent rectal cancer. Ann Surg Oncol 2007;14(2):447–54.
42. Salo J.C., Paty P.B., Guillem J. et al. Surgical salvage of recurrent rectal carcinoma after curative resection: a 10-year experience. Ann Surg Oncol 1999;6(2): 171–7.
43. Thaysen H.V., Jess P. and Laurberg S. Health-related quality of life after surgery for primary advanced rectal cancer and recurrent rectal cancer: a review. Colorectal Dis 2012;14(7):797–803.
44. Morken J.J., Baxter N.N., Madoff R.D., Finne C.O. 3rd. Endorectal ultrasound-directed biopsy: a useful technique to detect local recurrence of rectal cancer. Int J Colorectal Dis 2006;21(3):258–64.
45. Dan'ko N.A., Vazhenin A.V. and Nadvikova E.A. [Value of magnetic resonance imaging in the diagnosis of recurrent colorectal cancer]. Vestn Rentgenol Radiol 2012;3:28–33.
46. Colosio A., Fornès P., Soyer P. et al. Local colorectal cancer recurrence: pelvic MRI evaluation. Abdom Imaging 2013;38(1):72–81.
47. Ho M.L., Liu J.and Narra V. Magnetic resonance imaging of rectal cancer. Clin Colon Rectal Surg 2008;21(3):178–87.
48. Abir F., Alva S., Longo W.E. et al. The postoperative surveillance of patients with colon cancer and rectal cancer. Am J Surg 2006;192(1):100–8.
49. Stückle C.A., Haegele K.F., Jendreck M. et al. [Improvements in detection of rectal cancer recurrence by multiplanar reconstruction]. Radiologe 2005;45(10): 930–4, 936.
50. Blomqvist L., Holm T., Göranson H. et al. MR imaging, CT and CEA scintigraphy in the diagnosis of local recurrence of rectal carcinoma. Acta Radiol 1996;37(5):779–84.
51. Pema P.J., Bennett W.F., Bova J.G., Warman P. CT vs MRI in diagnosis of recurrent rectosigmoid carcinoma. J Comput Assist Tomogr 1994;18(2):256–61.
52. Petersen H., Nielsen M.J., Høilund-Carlsen M. et al. PET/CT may change diagnosis and treatment in cancer patients. Dan Med Bull 2010;57(9):A4178.
53. Shamim S.A., Kumar R., Shandal V. et al. FDG PET/CT evaluation of treatment response in patients with recurrent colorectal cancer. Clin Nucl Med 2011;36(1):11–6.
54. Maas M., Rutten I.J., Nelemans P.J. et al. What is the most accurate whole-body imaging modality for assessment of local and distant recurrent disease in colorectal cancer? A meta-analysis : imaging for recurrent colorectal cancer. Eur J Nucl Med Mol Imaging 2011;38(8):1560–71.
55. The Association of Coloproctology of Great Britain and Ireland. Guidelines for the management of colorectal cancer, 3rd edition (2007). URL: http://www.acpgbi.org.uk (дата обращения 01.03.2012).
56. Harji D.P., Griffiths B., McArthur D.R., Sagar P.M. Surgery for recurrent rectal cancer: higher and wider? Colorectal Dis 2013;15(2):139–45.
57. Bhangu A., Ali S.M., Cunningham D. et al. Comparison of long-term survival outcome of operative vs nonoperative management of recurrent rectal cancer. Colorectal Dis 2013;15(2):156–63.
58. Rödel C., Grabenbauer G.G., Matzel K.E. et al. Extensive surgery after high-dose preoperative chemoradiotherapy for locally advanced recurrent rectal cancer. Dis Colon Rectum 2000;43(3):312–9.
59. Vermaas M., Ferenschild F.T., Nuyttens J.J. et al., Preoperative radiotherapy improves outcome in recurrent rectal cancer. Dis Colon Rectum 2005;48(5):918–28.
60. Mohiuddin M., Marks G. and Marks J. Long-term results of reirradiation for patients with recurrent rectal carcinoma. Cancer 2002;95(5):1144–50.
61. Valentini V., Morganti A.G., Gambacorta M.A. et al. Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study. Int J Radiat Oncol Biol Phys 2006;64(4):1129–39.
62. Hu J.B., Sun X.N., Yang Q.C. et al. Three-dimensional conformal radiotherapy combined with FOLFOX4 chemotherapy for unresectable recurrent rectal cancer. World J Gastroenterol 2006;12(16):2610–4.
63. Wang J.J., Yuan H.S., Li J.N. et al. Interstitial permanent implantation of 125I seeds as salvage therapy for re-recurrent rectal carcinoma. Int J Colorectal Dis 2009 Apr;24(4):391–9.
64. Hartley J.E., Lopez R.A., Paty P.B. et al. Resection of locally recurrent colorectal cancer in the presence of distant metastases: can it be justified? Ann Surg Oncol 2003;10(3):227–33.
65. Saito N., Koda K., Takiguchi N. et al. Curative surgery for local pelvic recurrence of rectal cancer. Dig Surg 2003;20(3):192–9; discussion 200.
66. Dozois E.J., Privitera A., Holubar S.D. et al. High sacrectomy for locally recurrent rectal cancer: Can long-term survival be achieved? J Surg Oncol 2011;103(2):105–9.
67. Nielsen M.B., Rasmussen P.C., Lindegaard J.C., Laurberg S. A 10-year experience of total pelvic exenteration for primary advanced and locally recurrent rectal cancer based on a prospective database. Colorectal Dis 2012;14(9):1076–83.
68. Moore H.G., Shoup M., Riedel E. et al. Colorectal cancer pelvic recurrences: determinants of resectability. Dis Colon Rectum 2004;47(10):1599–606.
69. Zhao J., Du C.Z., Sun Y.S., Gu J. Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment. World J Gastroenterol 2012;18(47):7015–20.
70. Kusters M., Dresen R.C., Martijn H. Radicality of resection and survival after multimodality treatment is influenced by subsite of locally recurrent rectal cancer. Int J Radiat Oncol Biol Phys 2009;75(5):1444–9.
71. Hellinger M.D. and Santiago C.A. Reoperation for recurrent colorectal cancer. Clin Colon Rectal Surg 2006;19(4):228–36.
72. De Wever I. Pelvic exenteration: long-term oncological results in a series of 106 patients. Acta Chir Belg 2011;111(5):282–7.
73. Moriya Y. Treatment strategy for locally recurrent rectal cancer. Jpn J Clin Oncol 2006;36(3):127–31.
74. Suo J. and Xia M.J. Surgical treatment strategies for the local recurrence of rectal cancer. Chin J Pract Surg 2012;32(9):785–6, 789.
75. Jager E., Heike M., Bernhard H. et al. Weekly high-dose leucovorin versus low-dose leucovorin combined with fluorouracil in advanced colorectal cancer: results of a randomized multicenter trial. Study Group for Palliative Treatment of Metastatic Colorectal Cancer Study Protocol 1. J Clin Oncol 1996;14(8):2274–9.
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