Трифлуридин / типирацил (FTD / TPi, TAs-102) в лечении больных метастатическим раком толстой кишки: от предклинических экспериментов до рутинной практики
https://doi.org/10.17650/2686-9594-2020-10-3-4-11-26
Аннотация
Появление новых опций терапии с каждым годом приближает метастатический рак толстой кишки к понятию действительно хронического заболевания, которое может протекать годами. Одной из таких опций является новый химиопрепарат трифлуридин / типирацил (FTD / TPI, TAS-102), уже зарегистрированный более чем в 60 странах. Он позволяет увеличить продолжительность жизни пациентов при приемлемом уровне нежелательных явлений, чей спектр в основном представлен гематологическими осложнениями. В настоящем обзоре литературы будут рассмотрены все аспекты, связанные с данным препаратом, – от изучения фармакокинетики и определения максимально переносимой дозы, возможности применения при нарушениях функции печени до результатов комбинации препарата с таргетной терапией и сравнения с другими лечебными подходами у химиорефрактерных больных метастатическим раком толстой кишки.
Об авторе
М. Ю. Федянин
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России; ФГАОУ ВО «Российский университет дружбы народов»; ГБУЗ г. Москвы «Городская клиническая больница № 40 Департамента здравоохранения г. Москвы»
Россия
Россия
115478 Москва, Каширское шоссе, 24; кафедра онкологии и гематологии факультета непрерывного медицинского образования, 117198 Москва, ул. Миклухо-Маклая, 21, корп. 3; 129301 Москва, пос. Коммунарка, ул. Сосенский стан, 8
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