Neoadjuvant chemoradiation therapy for locally advanced colorectal cancer in hypofractionation mode (case report)
https://doi.org/10.17650/2686-9594-2019-9-4-48-56
Abstract
This article demonstrates the experience of successful treatment of a patient with locally advanced rectal cancer, who received a combined treatment with a non-standard course of chemoradiotherapy in hypofractionation mode according to a prolonged program. After the end of a course of chemoradiation received the complete clinical response of the tumor.
About the Authors
S. I. Tkachev
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
A. S. Abduzhapparov
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
V. A. Aliev
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
Yu. A. Barsukov
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
J. M. Madyarov
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
Russian Federation
24 Kashirskoe Shosse, Moscow 115 478
References
1. Wiggers T. Multidisciplinary treatment of locally advanced rectal cancer. Eur J Cancer 2007;5(Suppl):375–6.
2. Sauer R., Becker H., Hohenberger W. et al. Preoperative chemo/radiotherapy as compared with post-operative chemo/radiotherapy for locally advanced rectal cancer. N Engl J Med 2004;351(17):1731–40. DOI: 10.1056/NEJMoa040694.
3. Yi Li, Ji Wang, Xiaowei Ma et al. A review of neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Int J Biol Sci 2016;12(8):1022–31. DOI: 10.7150/ ijbs.15438.
4. Ognerubov N.A., Artamonova E.V. New approaches to the treatment of locally advanced rectal cancer. Vestnik TGU = Bulletin of Tomsk State University 2012;17(2):638–41. (In Russ.).
5. Erlandsson J., Holm T., Pettersson D. et al. Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer (Stockholm III): a multicentre, randomised, non-blinded, phase 3, non-inferiority trial. Lancet Oncol 2017;18(3):336–46. DOI: 10.1016/S14702045(17)30086-4.
6. Evans J., Bhoday J., Sizer B. et al. Results of a prospective randomised control 6 vs 12 trial: is greater tumour downstaging observed on post treatment MRI if surgery is delayed to 12-weeks versus 6-weeks after completion of neoadjuvant chemoradiotherapy. Ann Oncol 2016;27(Suppl 6):vi149 (abstr. 4520). DOI: 10.1093/annonc/mdw370.01.
7. Lefevre J.H., Mineur L., Kotti S. et al. Effect of interval (7 or 11 weeks) between neoadjuvant radiochemotherapy and surgery on complete pathologic response in rectal cancer: a multicenter, randomized, controlled trial (GRECCAR-6). J Clin Oncol 2016;34(31):3773–80. DOI: 10.1200/JCO.2016.67.6049.
8. Барсуков Ю.А., Ткачев С.И., Николаев А.В. и др. Комплексное лечение больных с раком прямой кишки с использованием неоадъювантной термохимиолучевой терапии. Онкологическая колопроктология 2014;(3):23–8.
9. Brenner D.J. Fractionation and late rectal toxicity. Int J Radiat Oncol Biol Phys 2004;60(4):1013–5. DOI: 10.1016/j.ijrobp.2004.04.014.
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