THE HIGH ACTIVITY OF VECTIBIX IN PATIENTS WITH METASTATIC COLORECTAL CANCER WITH THE RAS WILD-TYPE GENE
https://doi.org/10.17650/2220-3478-2014-0-2-18-21
Abstract
High-efficiency inhibitors of EGFR (panitumumab and cetuximab) in combination with chemotherapy in patients with advanced colorectal cancer is the result of the targeting special group of the patients based on studies of genes. Previously it was shown that the presence of mutation in exon 2 of KRAS gene (40 % of patients) determines the effectivity of this group of drugs. However, the search for additional indicators was continued. The result is that the presence of mutations in exons 3 and 4 of KRAS gene and in exons 2, 3 and 4 of NRAS gene also predict EGFR inhibitors efficacy. These mutations are defined in 10 % of patients. Analysis showed that the efficiency of panitumumab and cetuximab in combination with chemotherapy significantly increased in patients with wild-type KRAS and NRAS.
About the Author
N. N. Semenov
Department of Chemotherapy and Combination Treatment for Malignant Tumors, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
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