CHARACTERISTICS OF CLINICAL COURSE OF METASTATIC AND PRIMARY OVARIAN TUMORS IN COLON CANCER
https://doi.org/10.17650/2220-3478-2015-1-49-53
Abstract
The aim of this study was to investigate clinical pecuiliarities of ovarian tumors in colon cancer patients and determination of complex diagnostic methods.
Subject and methods. Russian N.N. Blokhin Cancer Research Center archives were used for retrospective study, patients, who underwent treatment during 1989–2013 were included. Colon cancer patients with ovarian metastases and with synchronous or metachronous tumors were included.
Results. 141 patients were included: 91 patients had colon cancer with ovarian metastases (group 1) and 50 patients had synchronous or metachronous ovarian tumours (group 2). Ovarian tumors were diagnosed during the 1 year in 74 (81.3 %) patients in group 1 and in 23 (46 %) in group 2. Patients in group 2 less frequently had children (9 (18.0 %) vs 5 (5.5 + 2.3 %), р < 0.05), family history of cancer (3 (6 %) vs 16 (17.6 %), р < 0.05) and concomitant diseases. Median CA 125 level in group 1 was 64.96 ng/ml and 180 ng/ml in group 2. Ovarian tumors had solid and cystic structure during US examination in 66 (73 %) patients in group 1 and 31 (62 %) patients in group 2 had solid ovarian tumors on US examination.
Conclusions. The differential diagnostics of primary and metastatic ovarian tumors must include CEA, CA 19–9 and CA 125 serum levels and pelvic US.
About the Authors
I. A. Dzhanyan
N.N. Blokhin Russian Cancer Research Center
Russian Federation
N.N. Blokhin Russian Cancer Research Center; 24 Kashirskoye Shosse, Moscow, 115478, Russia
Russian Federation
N.N. Blokhin Russian Cancer Research Center; 24 Kashirskoye Shosse, Moscow, 115478, Russia
I. G. Komarov
N.N. Blokhin Russian Cancer Research Center
Russian Federation
N.N. Blokhin Russian Cancer Research Center; 24 Kashirskoye Shosse, Moscow, 115478, Russia
Russian Federation
N.N. Blokhin Russian Cancer Research Center; 24 Kashirskoye Shosse, Moscow, 115478, Russia
Y. G. Payanidi
N.N. Blokhin Russian Cancer Research Center
Russian Federation
N.N. Blokhin Russian Cancer Research Center; 24 Kashirskoye Shosse, Moscow, 115478, Russia
Russian Federation
N.N. Blokhin Russian Cancer Research Center; 24 Kashirskoye Shosse, Moscow, 115478, Russia
References
1. Казакевич В.И., Митина Л.А., Востров А.Н., Гуц О.В. Ультразвуковая диагностика метастатического поражения яичников при раке желудочно-кишечного тракта. Ультразвуковая и функциональная диагностика 2009;5:14. [Kazakevitch V.I., Mitina L.A., Vostrov A.N. Guts O.V. Ultrasound diagnosis of metastatic disorder of ovarian in cancer of the gastrointestinal tract. Ultrazvukovaya i funktsionalnaya diagnostika = Ultrasound and functional diagnostics 2009;5:14 (In Russ.)].
2. Казаков М.П., Поддубная И.В., Любченко Л.Н., Харитонова Т.В. Наследственный рак яичника (литературный обзор). Современная онкология 2012;1(14):47–54. [Kazakov M.P., Poddubnaya I.V., Lubchenco L.N., Kharitonova T.V. Hereditary ovarian cancer (literature review). Sovremennaya onkologiya = Modern oncology 2012;1(14):47–54 (In Russ.)].
3. Паяниди Ю.Г., Сельчук В.Ю., Жордания К.И. и др. Полинеоплазии жен- ского генитального тракта: первично-мно- жественные новообразования или метастазы? Архив патологии 2006;4:16–20. [Payanidi Y.G., Selchuk V.Y., Jordania K.I. et al. Polyneoplasia of female genital tract: multiple primary tumors or metastases? Arkhiv patologii = Archives of pathology 2006;4: 16–20 (In Russ.)].
4. Паяниди Ю.Г., Сельчук В.Ю., Жордания К.И. и др. Первично-множественные злокачественные новообразования половых органов у женщин: пути профилактики. Опухоли женской репродуктивной системы 2010;1:51–4. [ Payanidi Y.G., Selchuk V.Y., Jordania K.I. et al. Multiple primary malignant neoplasms of genital organs in women: the way of prevention. Opukholi zhenskoy reproduktivnoy sistemy = Tumors of the female reproductive system 2010;1: 51–4 (In Russ.)].
5. Попова Т.Н. Диагностика и лечебная тактика у больных с первично-множественными синхронными злокачественными опухолями. Дис. … д-ра мед. наук. М., 2002. [Popova T.N. Diagnosis and treatment strategy in patients with multiple primary synchronous malignant tumors. Thesis ... Dr. sci. med. M., 2002 (In Russ.)].
6. Kim D.D., Park I.J., Kim H.C. et al. Ovarian metastases from colorectal cancer: a clinicopathological analysis of 103 patients. Colorectal Dis 2009 Jan;11(1):32–8.
7. Omranipour R., Abasahl A. Ovarian metastases in colorectal cancer. Int J Gynecol Cancer 2009 Dec;19(9):1524–8.
8. Simon M.S., Petrucelli N. Hereditary breast and ovarian cancer syndrome: the impact of race on uptake of genetic counseling and testing. Methods Mol Biol 2009;471:487–500.
9. La Vecchia C. Epidemiology of ovarian cancer: a summary review. Eur J Cancer Prev 2001;10:125–9.
Review
Views:
1983
Email this article 